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THE
FACE
OF
Evolysse™ is the first injectable hyaluronic acid made with next-generation Cold-X™ Technology by Symatese
Evolysse is made with innovative Cold-X Technology, which represents an advancement in the manufacturing of injectable hyaluronic acid gels. Cold-X Technology crosslinks at near-freezing temperatures, aimed at preserving the natural structure of the HA molecule.
EVOLYSSE PRESERVES:
THE FIRST INNOVATION IN HA TECHNOLGY IN OVER A DECADE
HA
Get the Cold-X Hard Facts
FRAGMENTS
BDDE
PRESERVES
PERFORMS
PROVES
Performs in the treatment area and is designed to soften wrinkles and creases that form in dynamic areas of the face, such as the nasolabial folds. 1,2
EVOLYSSE PERFORMS:
THE FIRST INNOVATION IN HA TECHNOLGY IN OVER A DECADE
See Why Our Gels Excel
PRESERVES
PERFORMS
PROVES
Evolysse Smooth
Evolysse Form
Evolysse Form and Evolysse Smooth were compared with Restylane-L in a non-inferiority clinical study.*
CLINICAL STUDY HIGHLIGHTS1,2
THE FIRST INNOVATION IN HA TECHNOLGY IN OVER A DECADE
Explore Clinical Study Data
Both met the primary endpoint vs control†
The first injectable HA to demonstrate non-inferiority & statistical superiority at 6 months vs Restyle -L in a pivotal trial*
Both had no delayed onset nodules
PRESERVES
PERFORMS
PROVES
All subjects in the study (n=140) received initial treatment and were offered an optional touch-up at 2 weeks. All patients also had the choice of optional retreatment at 12 months.1,2
CLINICAL STUDY FLOWCHART
THE RESULTS ARE CLEAR
U.S. NLF Pivotal Study*
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
The first injectable HA to demonstrate non-inferiority and statistical superiority at 6 months vs Restyle-L in a pivotal trial.*
PRIMARY ENDPOINT1,2
THE RESULTS ARE CLEAR
Nasolabial Fold
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
At 6 months after treatment, more than 92% of those receiving Evolysse Form had a ≥1-point improvement from baseline on the Wrinkle Severity Rating Scale (Blinded Evaluator).*
RESULTS1,2
THE RESULTS ARE CLEAR
Responder rates at month 6*
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
More than 93% of those receiving Evolysse Smooth had a ≥1-point improvement.*
(Defined as ≥1-point improvement on the Wrinkle Severity Rating Scale*)
Evolysse Form showed statistically significant differences compared to Restylane-L at all measured timepoints for the entire 12-month study period.†
HEAD TO HEAD
THE RESULTS ARE CLEAR
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
Evolysse Smooth showed statistically
significant differences compared to Restylane-L
at 6 and 9 months.†
Change from baseline on the WSRS at each timepoint, as determined by the Blinded Evaluator
In the clinical trial, the mean injection volume for Evolysse Form and Evolysse Smooth was less than Restylane-L to achieve optimal correction.
INJECTION VOLUME1,2
THE RESULTS ARE CLEAR
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
More than 95% of patients had improvement 
on the GAIS at 6 months after treatment with Evolysse Form.*
AESTHETIC IMPROVEMENT1,2
THE RESULTS ARE CLEAR
EFFICACY
PRIMARY ENDPOINT
RESULTS
HEAD TO HEAD
INJECTION VOLUME
AESTHETIC
IMPROVEMENT
More than 98% of patients had improvement 
on the GAIS at 6 months after treatment with Evolysse Smooth.*
Global Aesthetic Improvement Scale (GAIS)
Improvement at month 6*
Videos & Visuals
GEL FORMULATIONS
GEL PERFORMANCE
INJECTION TECHNIQUE
Evolysse Form
Evolysse Smooth
Common injection techniques include retrograde linear threading, crosshatching, fanning, and serial puncture1-3
INJECTION TECHNIQUES
GEL PERFORMANCE
INJECTION TECHNIQUE
Common injection techniques include:
Serial puncture
Retrograde linear threading
Crosshatching
Fanning
Viscoelasticity:
a property of materials that exhibit both viscous and elastic characteristics under deformation
RHEOLOGY OVERVIEW4-6
WHAT SETS APART EVOLYSSE FORM AND EVOLYSSE SMOOTH
RHEOLOGY
GEL PROPERTIES
INJECTION DEPTH
Elasticity (G'):
measures gel firmness (resistance to shearing and twisting)
Viscosity (G"):
measures gel flow (liquid or fluid-like behavior)
Tan Delta:
ratio of G” to G’
DESIGNED TO ACHIEVE
A RANGE OF TREATMENT GOALS
RHEOLOGY
GEL PROPERTIES
INJECTION DEPTH
WHAT SETS APART EVOLYSSE FORM AND EVOLYSSE SMOOTH
for dynamic facial wrinkles or folds*
RHEOLOGY
GEL PROPERTIES
INJECTION DEPTH
DEPTH
WHAT SETS APART EVOLYSSE FORM AND EVOLYSSE SMOOTH
Evolysse Form and Evolysse Smooth are indicated for dermal and subdermal injection to correct dynamic facial wrinkles and folds.1,2
BEFORE & AFTER
SAFETY IS COOL
PATIENT SATISFACTION
SAFETY
The most common side effects were temporary and at the injection site, such as tenderness, swelling, bruising, pain, redness, and lumps.1,2
Adverse events*
GIVE YOUR PATIENTS REASONS TO SMILE
PATIENT SATISFACTION
SAFETY